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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK2 All Species: 18.18
Human Site: Y178 Identified Species: 28.57
UniProt: Q92630 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92630 NP_003574.1 601 66652 Y178 E H H E I F S Y P E I Y F L G
Chimpanzee Pan troglodytes XP_509205 601 66595 Y178 E H H E I F S Y P E I Y F L G
Rhesus Macaque Macaca mulatta XP_001117134 601 66643 Y178 E H H E I F S Y P E I Y F L G
Dog Lupus familis XP_538273 601 66656 Y178 E H H E I F S Y P E I Y F L G
Cat Felis silvestris
Mouse Mus musculus Q5U4C9 599 66538 Y201 G G P N N G G Y D D D Q G S Y
Rat Rattus norvegicus Q4V8A3 586 65492 G187 V I G G P N N G G Y D D A D G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511087 546 60615 H188 Q V V K A F D H K A Q H H V A
Chicken Gallus gallus Q5ZIU3 526 59419 L175 K M H Q H V A L K M V R N E K
Frog Xenopus laevis NP_001088793 567 63329 V185 N L V P H D H V A Y R Y E V L
Zebra Danio Brachydanio rerio NP_001038298 587 65453 G188 V V G G S N N G G Y D D D Q G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P83102 828 92722 T232 Y E R T E I L T Y P Q I Y F I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001023208 796 87422 Y417 E K N E I Y N Y T R V F F V G
Sea Urchin Strong. purpuratus XP_799140 561 63192 G179 C G Y D D D Q G S Y I H V Q H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51566 467 54180 Q116 D T L T P R Y Q I L S K M G E
Baker's Yeast Sacchar. cerevisiae P14680 807 91227 Q325 C S P E F T Y Q T S K N P K R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 99.6 98.3 N.A. 97 59.7 N.A. 78.6 81.3 64.5 83.6 N.A. 43.3 N.A. 45.7 63.7
Protein Similarity: 100 98.8 99.8 99 N.A. 98.5 71.8 N.A. 83 84.5 75 89.8 N.A. 54.9 N.A. 55.6 73.5
P-Site Identity: 100 100 100 100 N.A. 6.6 6.6 N.A. 6.6 6.6 6.6 6.6 N.A. 0 N.A. 40 6.6
P-Site Similarity: 100 100 100 100 N.A. 13.3 13.3 N.A. 40 33.3 13.3 13.3 N.A. 6.6 N.A. 80 26.6
Percent
Protein Identity: N.A. N.A. N.A. 21.3 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 36.6 41.2 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 7 0 7 7 0 0 7 0 7 % A
% Cys: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 7 7 14 7 0 7 7 20 14 7 7 0 % D
% Glu: 34 7 0 40 7 0 0 0 0 27 0 0 7 7 7 % E
% Phe: 0 0 0 0 7 34 0 0 0 0 0 7 34 7 0 % F
% Gly: 7 14 14 14 0 7 7 20 14 0 0 0 7 7 47 % G
% His: 0 27 34 0 14 0 7 7 0 0 0 14 7 0 7 % H
% Ile: 0 7 0 0 34 7 0 0 7 0 34 7 0 0 7 % I
% Lys: 7 7 0 7 0 0 0 0 14 0 7 7 0 7 7 % K
% Leu: 0 7 7 0 0 0 7 7 0 7 0 0 0 27 7 % L
% Met: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % M
% Asn: 7 0 7 7 7 14 20 0 0 0 0 7 7 0 0 % N
% Pro: 0 0 14 7 14 0 0 0 27 7 0 0 7 0 0 % P
% Gln: 7 0 0 7 0 0 7 14 0 0 14 7 0 14 0 % Q
% Arg: 0 0 7 0 0 7 0 0 0 7 7 7 0 0 7 % R
% Ser: 0 7 0 0 7 0 27 0 7 7 7 0 0 7 0 % S
% Thr: 0 7 0 14 0 7 0 7 14 0 0 0 0 0 0 % T
% Val: 14 14 14 0 0 7 0 7 0 0 14 0 7 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 7 14 40 7 27 0 34 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _